Neuromuscular

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NERVE BIOPSY

Diagnoses to look for
Pathology & Illustrations
Indications & Utility
Results: Differential diagnoses
Technical (Preparation)
  Freezing
Test form

Skin biopsy
Nerve fascicle: Normal numbers of small and large axons

NFH + Peripherin stain


Useful biopsy results more likely

Oppenheim
Nerve biopsy: Diagnoses to look for

BIOPSY FINDINGS IN NEUROPATHY

Morphologic changes in nerve or muscle: Differential diagnoses Other nerve pathology Other pathology in neuropathy: Denervation of muscle

Neurofilament accumulations in neuropathy
SMI 31 antibody
Sural nerve axons (Normal): Neurofilament stain


Mitochondrial abnormalities in neuropathy

Polyglucosan bodies

Tomaculae 1

Subperineurial clear space (Edema)

INFLAMMATORY OR IMMUNE NEUROPATHIES

Diseases Cellular infiltrates in nerve: Inferences from cell types & location Other pathological features of immune or inflammatory neuropathies

Skin Biopsy: Analysis of cutaneous nerves


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References
1. JNNP 2000;68:483-488

12/1/2013