Home, Search, Index, Links, Pathology, Molecules, Syndromes,
Muscle, NMJ, Nerve, Spinal, Ataxia, Antibody & Biopsy, Patient Info


  Axon relations
  Other components
  Pathology: Images
  Schmidt-Lanterman cleft
Node of Ranvier
Schwann cell
  Components: Non-myelinating
  Components: Other

Theodor Schwann

Leeuwenhoek, A. van, 1719 7

Spinal Nerve: From cow or sheep

Ranvier, L., 1872 8

Node of Ranvier: Rabbit

Ramon y Cajal 1909

Myelin Internode

Myelinated axon + Schwann cell cytoplasm Schwann Cell Development 2

Schwann cells & Myelin: Domains & Structure

Molecules in selective peripheral myelin & Schwann cell regions

Myelin Glycoproteins 1

P0 Location: Compact PNS myelin
Abundant: 50% of PNS myelin proteins
Molecular: Contains sulfated N-glycans; 30-kDa
Function: Stabilizes intraperiod line of compact PNS myelin by homophilic interactions
Diseases: CMT 1B; Dejerine-Sottas (CMT III);
    Congenital Hypomyelinating neuropathy
Myelin associated glycoprotein Locations
  Cells: Myelin-forming oligodendrocytes & Schwann cells
  Membranes: Periaxonal Schwann cell; ? Abaxonal
Molecular: 100 kDa
  N-linked glycosylation: 30% by weight; Contain sialic acid, sulfate & GlcNAc
  Binds to α2,3-linked sialic acids
Function: Axon-Glia interactions; Schmidt-Lanterman clefts
Disease: Anti-MAG neuropathy
Peripheral myelin protein-22 (PMP-22) Location: Compact PNS myelin
Molecular: 22-kDa
  Similar to PLP/DM-20 & OTM in CNS
  4 hydrophobic transmembrane domains
Forms complexes with P0 in myelin membranes Disease: CMT 1A
170 kDa glycoprotein (SAG)PNS Schwann cells & myelin
Schwann cell myelin protein (SMP)Homology to MAG
? present in humans
Myelin/Oligodendrocyte glycoprotein (MOG) Location: External surface of oligodendrocytes & CNS myelin
Oligodendrocyte-myelin glycoprotein (OMgp) Location: CNS myelin
General properties
  • Many are members of immunoglobulin superfamily
  • Often express HNK-1 carbohydrate epitope
  • Carbohydrate epitope may be involved in homophilic cell-cell interactions
  • Glycosylation
    • PNS: Major myelin proteins glycosylated
    • CNS: Major myelin proteins not glycosylated

Nodes of Ranvier & Associated Structures 6

Internode Juxtaparanode Compact myelin Compact myelin Paranode Node of Ranvier

Node of Ranvier

Myelinated axon near
Paranode & Node of Ranvier
Paranode Juxtaparanode Internodal region: Components

Other myelin-related components

Non-myelinating & Denervated Schwann cell components

Other Schwann cell components

Early growth response (EGR) genes

Myelin-Associated Glycoprotein (MAG; siglec-4) 1,4

Return to Neuromuscular Home Page
Return to Demyelinating neuropathies

1. J. Molec Neurosci 1997;7:1-12, Cell Mol Life Sci 2002;59:1851–1871, J Neurol Sci 2005;228:187-189
2. Trends Neurosci 1999;22:402-410, Journal of Peripheral Nervous System 2008;13:122–135
3. Brain 2000;123:222-233
4. Glia 2000;29:154-165
5. Neuron 2001;30:677-687
6. J Periph Nerv Sys 2002;7:1-12, Glia 2008;56:1532-1540
7. Leeuwenhoek, A. van, 1719. Epistola XXXII (p. 312)
  in Epistolae physiologicae super compluribus naturae arcanis,
  Adrianum Beman, Delft.

8. Ranvier, L., 1872. Recherches sur l’histologie et la physiologie des nerfs.
Archives de Physiologie Normale et Pathologique, 4, 129-149.