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| Stage | Associated genetic factors | Mutant effects |
| Delamination | Pax3; c-met | Pax3 mutant: No c-met expression; No lateral migration |
| Migration | c-met/HGF; Lbx1 | Migration does not occur |
| Proliferation | ? Pax3; c-met; Mox2; Msx1; Six; (Myf5; MyoD) | No proliferation |
| Determination | Myf5; MyoD | Myf5 + MyoD muations: Myogenic cell adopts non-muscle phenotype |
| Differentiation | Myogenin; Mcf2; Six; (MyoD; Myf6) | Mutants remain as myocytes |
| Specific muscle formation |
Lbx1; Mox2 | Lbx1 mutants: Extensor & Hindlimb muscle Mox-2 mutants: Forelimb & Hindlimb muscle |
| Satellite cells | Pax7 | Satellite cells absent; No postnatal muscle growth |
Dorsal![]() Ventral
Sclerotome
Mesenchymal cells Location: Ventral somite Derivatives: Ribs & Vertebrae Dermomyotome Epithelial structure Forms from somites Location: Dorsal somite Derivatives: Skin & Skeletal muscles Epaxial: Back muscles Hypaxial: Trunk & Limb muscles Myotome Origin: Dermomyotome Derivative: Trunk muscle DRG: Dorsal root ganglion |
![]() PAX 7 stain
Satellite cells in Duchenne MD
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Muscle Regeneration: Pathways
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