|
Aggregates Inflammation MHC Class-1 up-regulation Mitochondrial changes |
![]() H & E stain |
![]() Acid phosphatase stain |
![]() CD4 stain |
Focal invasion of muscle fibers
|
||
![]() Gomori trichrome |
Inflammatory cells in endomysium
|
![]() Acid phosphatase |
![]() Acid phosphatase |
|
|
![]() ![]() Congo red stained muscle fibers |
|
Vacuoles
|
|
|
More vacuoles
|
|
|
|
Vacuoles may contain amyloid-like birefringent (red-green) material (Congo red stain)
|
![]() SMI-31 + Congo red stains |
![]() Congo Red + Fluorescence with Texas red filter |
SMI-31 positive aggregates in IBM
|
|
|
|
αB-crystallin
|
|
|
|
Ubiquitin conjugates: IBM
|
|
|
|
Valosin-containing protein (VCP): IBM
|
|
![]() Congo red + β-amyloid stain |
![]() Congo red + fluorescence |
β-Amyloid: IBM
|
|
![]() From: R Schmidt |
| Ultrastructure: Vacuoles contain tubulovesicular material |
![]() Normal |
![]() IBM |
|
MHC Class-1 up regulation
|
|