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Aggregates αB-crystallin β-Amyloid LC3 SMI-31 TDP-43 Ubiquitin VCP Inflammation MHC Class-1 up-regulation Mitochondrial changes Vacuoles Also see: PM-Mito |
![]() H & E stain |
![]() Acid phosphatase stain |
Focal invasion of muscle fibers
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![]() CD4 stain |
![]() CD3 stain |
![]() Gomori trichrome |
Inflammatory cells in endomysium
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![]() Acid phosphatase |
![]() Acid phosphatase |
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![]() ![]() Congo red stained muscle fibers |
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Vacuoles
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More vacuoles
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Vacuoles may contain amyloid-like birefringent (red-green) material (Congo red stain)
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![]() SMI-31 + Congo red stains |
![]() Congo Red + Fluorescence with Texas red filter |
SMI-31 positive aggregates in IBM
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αB-crystallin
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Ubiquitin conjugates: IBM
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Valosin-containing protein (VCP): IBM
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![]() Congo red + β-amyloid stain |
![]() Congo red + fluorescence |
β-Amyloid: IBM
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![]() Congo red + TDP43 |
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TDP-43: IBM
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![]() Congo red + TDP43 |
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![]() CD4 (Green) + TDP43 (Red) TDP-43: Aggregates & Inflammatory cells in IBM
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![]() SMI-31 (Green) + TDP43 (Red) TDP-43: Aggregates and cytoplasmic staining with varied relation to SMI-31 staining
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![]() Congo red + LC3 stain |
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| LC3: IBM |
![]() Congo red + LC3 stain |
![]() From: R Schmidt |
| Ultrastructure: Vacuoles contain tubulovesicular material |
![]() Normal |
![]() IBM |
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MHC Class-1 up regulation
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