Neuromuscular

MITOCHONDRIAL DISEASE: ULTRASTRUCTURE

Ultrastructural features of mitochondria in mitochondrial disease




Muscle mitochondria with normal structure.



Mitochondrial myopathy: Subsarcolemmal accumulation of mitochondria



Mitochondrial myopathy: Enlarged whorled mitochondrion

Mitochondrial disease: Abnormal muscle mitochondria from a child

Mitochondrial inclusions



Inclusions: Present in many mitochondria



Longitudinal sections of crystalloid inclusions



Cross sections of crystalloid inclusion

Cross sections of crystalloid inclusions



Cross section of dark crystalloid inclusion




Dense parallel cristae



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8/23/2013