Neuromuscular

LGMD 1A: Myotilin mutations


H & E stain; From: Drs Montse Olivé & Isidro Ferrer

Muscle fiber pathology
  Varied fiber size
  Abnormal internal architecture
    Hyaline inclusions
    Basophilic punctate material
  Vacuoles

H & E stain

H & E stain

H & E stain


Gomori Trichrome stain

Gomori Trichrome stain

Gomori Trichrome stain
Muscle fiber pathology
  Varied fiber size
  Vacuoles
  Inclusions
    Hyaline & Rod-like material

GT stain; From: Drs Montse Olivé & Isidro Ferrer

Gomori Trichrome stain

NADH stain

VvG stain

Internal architecture: Varied patterns

NADH stain

NADH stain

NADH stain

PROTEIN AGGREGATES

Myotilin stain
Myotilin aggregates in muscle fibers

 
VCP stain
VCP aggregates in muscle fibers

 
Desmin stain
Desmin aggregates in muscle fibers


Dystrophin stain
Dystrophin: Abnormal collections in muscle fiber cytoplasm

Dys2 stain

Return to Neuromuscular
Return to LGMD 1A

12/5/2013