MYOSITIS WITH MITOCHONDRIAL PATHOLOGY
Endomysial inflammation
Focal invasion of muscle fibers
Myopathic changes
Mitochondrial disorders
Other
INFLAMMATION: Predominantly Endomysial
H&E stain
H&E stain
MYOPATHY: Varied muscle fiber size; Increased connective tissue
MITOCHONDRIAL CHANGES
Cytochrome oxidase (COX) negative muscle fibers
Cytochrome oxidase stain
Succinate Dehydrogenase (SDH) positive muscle fibers
SDH stain
OTHER FEATURES
Perivascular Inflammation: Ocasional
MHC-I Upregulation on muscle fiber surface
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Inflammatory myopathies
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Polymyositis with mitochondrial disorders
6/26/2003
