Neuromuscular

Inflammatory Myopathies with Vacuoles, Aggregates & Mitochondrial Pathology (IM-VAMP)

Myositis with mitochondrial pathology (PM-Mito) subtype

Endomysial inflammation
Focal invasion of muscle fibers
Myopathic changes
Mitochondrial disorders
Other


INFLAMMATION: Predominantly Endomysial


H&E stain



H&E stain

MYOPATHY: Varied muscle fiber size; Increased connective tissue




MITOCHONDRIAL CHANGES

Cytochrome oxidase (COX) negative muscle fibers


Cytochrome oxidase stain

Succinate Dehydrogenase (SDH) positive muscle fibers


SDH stain

OTHER FEATURES

Perivascular Inflammation: Ocasional

MHC-I Upregulation on muscle fiber surface


LC-3 aggregates in muscle fibers


Return to Inflammatory myopathies
Return to Polymyositis with mitochondrial disorders

12/3/2011