Neuromuscular

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PROTEIN DEGRADATION1,2

General principles
Protease classes

Autophagy
Chaperones
Cysteine
Lysosomal
Metalloproteinases
Mitochondrial
Muscle
Serine
Ubiquitin-Proteasome

Also see
  Apoptosis
  Caspases
  External link: Prolysis


GENERAL PRINCIPLES


SERINE PROTEASES
CYSTEINE PROTEASES
LYSOSOMAL PROTEASES
METALLOPROTEINASE

UBIQUITIN-PROTEASOME PROTEIN DEGRADATION 3-5,7

Classes of proteases
Degradation pathway
Diagrams
Diseases
Related cellular processes
Ubiquitination

26S Proteasome


Degradation Pathway

End products
Large 26S proteasome
Overall process
Ubiquitin
Ubiquitin binding process
Ubiquitination regulated cellular processes

MITOCHONDRIAL PROTEASES


PROTEIN FOLDING & CHAPERONES8

Autophagy

General Chaperone-mediated autophagy Macroautophagy (Autophagy)
Steps in Autophagy


From: Chris Weihl
Disorders of Autophagy

MUSCLE PROTEIN DEGRADATION

INCREASED PROTEIN BREAKDOWN DECREASED PROTEIN BREAKDOWN
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References
1. NEJM 1996;335:1897-1905
2. Human Mutation 1999;13:87-98
3. Immunol Today 1997;18:189-198
4. FASEB J 1997;11;1067-1075
5. Cell Mol Life Sci 1998;54:253-262
6. J Neuroimmunol 1999;94:1-14, Sem Cancer Biol 2000;10:415-433
7. Annu. Rev. Immunol. 1999;17:739-779
8. Human Mutation 1999;14:199-215
9. Molec Genet Metab 2000:71:261-266

11/12/2013