Home, Search, Index, Links, Pathology, Molecules, Syndromes,
Muscle, NMJ, Nerve, Spinal, Ataxia, Antibody & Biopsy, Patient Info
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Home, Search, Index, Links, Pathology, Molecules, Syndromes, Muscle, NMJ, Nerve, Spinal, Ataxia, Antibody & Biopsy, Patient Info |
| Cerebellar lesion | Signs or Function |
| Posterior (Flocculo-nodular lobe; Archicerebellum) |
Eye movement disorders: Nystagmus; Vestibulo-ocular reflex (VOR) Postural and gait dysfunction |
| Midline (Vermis; paleocerebellum) | Truncal & gait ataxia |
| Hemisphere (Neocerebellum) | Limb ataxia: Dysmetria, Dysdiadochokinesis, "Intention" tremor Dysarthria Hypotonia |
| Afferent defect: Mossy fibers Vestibulopontine pathway Spinocerebellar system (Clarke) via: Inferior cerebellar peduncle |
Dysmetria Impaired stance & gait Information about body parts in space |
| Vestibulocerebellar system Vestibular nucleus to Flocculonodular lobe |
Situation & location of head |
| Outflow pathways: Dentate nucleus | Postural instability Limb ataxia |
| Inferior olive | Disturbed teaching error signals Ataxia developing over time: Especially trained limb movements (writing) |
| Disease | Dorsal root ganglion |
Clarke's column |
Vestibular nucleus |
Pontine nucleus |
Granule cells |
Purkinje cells |
Dentate nucleus |
Red nucleus |
Inferior olive |
| DRPLA | + | +++ | + | ||||||
| SCA6 | + | +++ | ++ | + | |||||
| SCA31 | +++ | ||||||||
| MSA | + | +++ | + | +++ | |||||
| SCA2 | ++ | +++ | +++ | +++ | ++ | + | +++ | ||
| SCA1 | ++ | + | + | ++ | ++ | ++ | ++ | ||
| SCA3 | +++ | ++ | ++ | + | +++ | ||||
| FRDA | +++ | +++ | ++ | + | +++ | ||||
| AOA1 | +++ | +++ | + | +++ | + | + |
Patient Resources
