Myopathy & Neuromuscular Junction  
    Disorders: Differential Diagnosis
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DISTRIBUTION OF WEAKNESS MUSCLE FEATURES TIME COURSE Vesalius
General
  Asymmetry
  Distal ≥ Proximal
    Hereditary
  Face & Periocular
    With EOM Weakness
    No EOM Weakness
  Limb-Girdle Syndromes
    Focal
  Bulbar
  Congenital
  EOM
  Finger extension
  Hamstring
  Paraspinous
  Posterior Neck
  Proximal Arms
    Elbow flexor
  Ptosis
  Quadriceps
  Respiratory
  Scapular

Weakness in most myopathies is
symmetric and maximal proximally.
Cramps
Muscle Fiber Activity
Muscle Size
  Large Muscles
  Weakness > Wasting
  Wasting > Weakness
  Absent
Pain
Tendon Reflexes
Acute
Episodic
Fatigue
  Myasthenia
Onset of weakness
  Congenital
  Infantile
Hereditary
SYSTEMIC FEATURES LAB FEATURES GENERAL TOPICS
Amyloid
Cardiac
  With Myopathy
  No myopathy
CNS
Endocrine
Gastro-Intestinal
Infections
Joint Contractures
Myoglobinuria
Neuropathy
Paraneoplastic
Renal
Respiratory Failure
Skeletal
Skin
Autoantibodies
Creatine Kinase (CK):
  Very High
  Unexpectedly High
  Low
Dystrophinopathy
Glycogen Storage
Immune & Inflammatory
Inclusion bodies
Ion Channel Disorders
Lipid Disorders
Mitochondrial Disorders
Muscle biopsy useful
Myofibrillar
Myosin Disorders
Pathology
Immunomodulating therapy
Muscle innervation
  Upper extremity
  Lower extremity
Neuromuscular Syndromes
Sports
Toxic
Typical Disease Patterns
Vitamins & Nutrition


See Neuromuscular Syndromes
Go to Differential Diagnosis of Neuropathies
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Other revisions

11/24/2014