Myopathy & Neuromuscular Junction  
    Disorders: Differential Diagnosis
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DISTRIBUTION OF WEAKNESS MUSCLE FEATURES TIME COURSE
General
  Asymmetry
  Distal ≥ Proximal
    Hereditary
  Face & Periocular
    · With EOM Weakness
    · No EOM Weakness
  Limb-Girdle Syndromes
     Focal
  Bulbar
  Congenital
  Hamstring
  Paraspinous
  Posterior Neck
  Proximal Arms
  Quadriceps
  Scapular
Weakness in most myopathies is
symmetric and maximal proximally.
Cramps
Muscle Fiber Activity
Muscle Size
 · Large Muscles
 · Weakness > Wasting
 · Wasting > Weakness
Pain
Tendon Reflexes
 Acute
Episodic
Fatigue
 · Myasthenia
Onset of weakness
 · Congenital
 · Infantile
Hereditary
SYSTEMIC FEATURES LAB FEATURES GENERAL TOPICS
Amyloid
Cardiac
 · With Myopathy
 · No myopathy
CNS
Endocrine
Gastro-Intestinal
Infections
Joint Contractures
Myoglobinuria
Neuropathy
Paraneoplastic
Renal
Respiratory Failure
Skeletal
Skin
 Autoantibodies
Creatine Kinase (CK):
 · Very High
 · Unexpectedly High
 · Low
Dystrophinopathy
Glycogen storage
Immune & Inflammatory
Inclusion bodies
Ion Channel Disorders
Lipid disorders
Mitochondrial Disorders
Muscle biopsy useful
Myosin Disorders
 Immunomodulating therapy
Muscle innervation
 · Upper extremity
 · Lower extremity
Neuromuscular Syndromes
Sports
Toxic
Typical Disease Patterns
Vitamins & Nutrition

See Neuromuscular Syndromes
Go to Differential Diagnosis of Neuropathies
Return to Neuromuscular Home Page
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Other revisions

3/19/2008