Neuromuscular

OCULOPHARYNGEAL MUSCULAR DYSTROPHY

Aggregates
Cytoplasmic bodies
Nuclear inclusions
Vacuoles


H&E stain

H&E stain
Fiber morphology
  Size: Varied
  Small fibers: Rounded or Angular; Some are basophilic
  Vacuoles: Occur in small fibers
  Internal nuclei: Occasional muscle fibers

Vacuoles


H&E stain

H&E stain

Gomori trichrome stain
Vacuoles
  May have rims (Above)
  Basophilic granular debris (Below)

Congo red stain

Gomori trichrome stain
Vacuoles
  Location: In small polygonal or angular muscle fibers
  Shape: Irregular
  Subcellular location: Peripheral (Sub-Sarcolemmal) or Central
  May be clear or contain red stained (GT) or granular material (Congo red)

Gomori trichrome stain


Congo red stain



NADH stain
Small fibers stain darkly on NADH

Caveolin-3 stain
Cytoplasmic aggregates

LC-3 stain

Nuclei: Tubulofilamentous Inclusions


Gomori trichrome stain
Internal nuclei: May have clear centers

Nuclear inclusions, Tubulofilamentous
·   Form tangles & palisades
·   Size: 8.5 nm diameter; Up to 0.25 μm length
·   ? Specific marker for disease


From Chunyu (Hunter) Cai
Nuclear inclusion: Small & Pale

From Chunyu (Hunter) Cai

From Chunyu (Hunter) Cai


From Chunyu (Hunter) Cai
Nuclear inclusion: Replaces most nuclear contents

From Chunyu (Hunter) Cai

OPMD: Cytoplasmic Bodies


Gomori trichrome stain
Cytoplasmic bodies: May be seen in some small muscle fibers

From Chunyu (Hunter) Cai

From Chunyu (Hunter) Cai


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6/12/2016