Neuromuscular

Immune Myopathies: MDA5 antibody-associated



H&E stain
Fiber size: Varied
Necrosis & Regeneration: Scattered

H&E stain


Gomori trichrome stain
Aggregates: Central; Irregular shapes


Acid phosphatase stain
Necrosis & Regeneration: Cells
  Scattered in endomysium
  Replacing necrotic muscle fibers

Esterase stain


ATPase pH 4.3 stain
Type 2 muscle fiber predominance


NADH stain
Internal architecture: Linearized in type 2 muscle fibers


LC3 stain
Aggregates: Punctate; Clustered

LC3 stain


MHC Class I stain
MHC Class I: Upregulated on all muscle fibers

MHC Class I stain


Ulex stain
Capillaries: Corkscrew shape

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References
1. Curr Opin Rheumatol 2011;23:595-604

3/8/2016