Cytoplasmic Bodies

Gomori Trichrome stain
Cytoplasmic bodies Structure Central region: Homogenous; Dark stain on Gomori trichrome similar to rods Outer zone: Radially oriented filaments; May contain actin Location Within cytoplasm: Central or subsarcolemmal Early stage: May be associated with Z-Band Disease associations Denervation: Especially in muscle fibers with targets Myopathies: Inflammatory; Myotonic; Periodic paralysis; ? Dystrophies Probably different from "Cytoplasmic bodies" described in cytoplasmic body or myofibrillar myopathies Rods: Also associated with abnormal Z-band structure

From Robert Schmidt MD Toluidine blue stain

From Robert Schmidt MD Ultrastructure