Neuromuscular

Home, Search, Index, Links, Pathology, Molecules, Syndromes,
Muscle, NMJ, Nerve, Spinal, Ataxia, Antibody & Biopsy, Patient Info


MEMBRANE-ASSOCIATED PROTEIN COMPLEXES IN
SKELETAL MUSCLE FIBERS & CONNECTIVE TISSUE

Extrajunctional muscle membrane: Associated proteins 2

Laminin 2: Congenital muscular dystrophy Agrin Biglycan alpha-Dystroglycan beta-Dystroglycan Integrin, alpha7: Congenital muscular dystrophyIntegrin, alpha7: Congenital muscular dystrophy Integrin, beta1 Dystrophin: Duchenne & Becker MD Caveolin-3: LGMD 1C Dysferlin: LGMD 2B alpha-Dystrobrevin gamma-Sarcoglycan: LGMD 2C beta-Sarcoglycan: LGMD 2E delta-Sarcoglycan: LGMD 2F alpha-Sarcoglycan: LGMD 2D zeta-Sarcoglycan Filamin 2 alpha1-Syntrophin beta1-Syntrophin sarcospan F-Actin Grb2 Calmodulin 1 NOS Syncoilin Collagen VI Basal lamina Membrane-associated proteins, Extrajunctional Muscle
General
Basal lamina & Connective tissue
Extrajunctional muscle
Muscle Membrane: Associated Proteins
Neuromuscular junction
Signalling complexes

Also see: Myosin & related proteins


Muscle Membrane: Associated proteins
Acetylcholine receptors: α, β, δ, e, γ
Acetylcholinesterase (A12)
Actin
Agrin (Muscle- & Nerve-derived)
AKAP9
Ankyrin
Biglycan
Calmodulin 1
Caveolin-3
Collagens
  α1 (IV); α2 (IV); α3 (IV); α4 (IV); α5 (IV)
  α1 (VI); α2 (VI); α3 (VI)
Contactin-1
Decorin
Dok-7
Dysferlin
Dystrobrevin
Dystrobrevin binding protein
α-Dystroglycan
β-Dystroglycan
Dystrophin
ErbB receptor tyrosine kinase
Fibronectin
Filamin-2 (Filamin C)
βGalNAc-terminal conjugates
Grb2
Heparan sulfate proteoglycans
Integrins
Laminins
LRP4
MASC
MuSK
NCAM
Neuregulins (ARIA)
Neurofascin
Nidogen
NOS
Perlecan
PHLDB2
Plectin
Rapsyn
Sarcoglycans
Sarcospan
Sodium channels, Voltage gated
S-Laminin
β-Spectrin
Syncoilin
SYNE1
Syntrophin
Utrophin
ZBTB42

Neuromuscular Junction: Associated proteins 1

NMJ-associated proteins
AChR, epsilon subunit AChR, alpha1 subunit AChR, beta1 subunit AChR, delta subunit AChR, alpha1 subunit Ion channel Muscle, skeletal, receptor tyrosine kinase Neural Agrin Rapsyn Rapsyn Acetylcholinesterase Perlecan Acetylcholine Receptors Lrp4 Plectin ErbB Receptor Laminin 4 F-Actin beta2-Syntrophin beta1-Syntrophin beta-Dystroglycan Utrophin Dok7

Muscle Membrane: Associated Proteins

Protein Complexes, Membrane-associated

Signalling Pathways


Muscle Membrane Proteins

Intracellular proteins associated with muscle membranes

Dystrobrevin
Dystrophin
Filamin 2
Syncoilin
Syntrophins

Extracellular matrix proteins

CONNECTIVE TISSUE COMPONENTS: SKELETAL MUSCLE
Collagen VI (Green) and Collagen IV (Orange) in muscle
Synaptic Extra-synaptic Synaptic & Extrasynaptic
Agrin (Nerve-derived)
Neuregulins (ARIA)
Acetylcholinesterase (A12)
Laminins: 4, 9, 11
S-laminin
Heparan sulfate proteoglycans
βGalNAc-terminal conjugates
Collagens
  α3 (IV); α4 (IV); α5 (IV)
NCAM
S-nidogen
Collagens
  α1 (IV); α2 (IV)
Laminin-2
Tenascin-XB
α-Dystroglycan
Nidogen
Fibronectin
Integrin-α7
Perlecan
Agrin (Muscle-derived)
Decorin
Collagens
  α1 (VI); α2 (VI); α3 (VI)
Biglycan

Dystroglycans and Other proteins associated with the dystrophin-sarcoglycan complex



HEPARAN SULFATE PROTEOGLYCANS (HSPG)

Integral memebrane "Amateur": Exist in glycosylated & non-glycosylated forms Membrane linkage by glycosyl phosphatidylinositol (GPI) Basement membrane Disorders External links: Interaction of angiogenic growth factors with Heparin/HS


LEUCINE-RICH REPEAT (LRR) PROTEINS

General features Small leucine rich proteoglycan (SLRP) subfamily
Return to Neuromuscular Home Page
Return to Neuromuscular Syndromes
Return to Limb-Girdle Syndromes

1. Current Opinion in Neurobiology 1997;7:379-384, Muscle Nerve 2002;25:4-16
2. Muscle Nerve 2001;24:1575-1594
3. Nature 2002;418:417-422, J Biochem 2014 Nov 7
4. Hum Molec Genet 2002;11:2147-2154
5. J Biol Chem 2003;278:12601-12604.
6. Nature Neurosci 2003;July
7. Circ Res. 2004;94:1023-1031
8. J Neuropathol Exp Neurol 2005;64:350–361
9. Muscle Nerve 2005: Online June
10. Neurology 2011 Oct 19, Neurology 2011 Oct 19
11. Curr Rheumatol Rep 2014;16:394

7/17/2017