Neuromuscular

DIFFERENTIAL FASCICULAR LOSS OF AXONS

Patchy axon loss is associated with

Gomori trichrome stain

Gomori trichrome stain

VvG stain
Variable loss of myelinated (red) axons in the same nerve.
  Severe loss of myelinated axons in a fascicle on the left.
  More myelinated axons remain in an adjacent fascicle (right)
Myelinated axon loss: More severe in larger fascicle (Right).

Myelinated axons: Variable loss among fascicles

H&E stain
Myelinated axons: Variable loss among fascicles

Gomori trichrome stain
Myelinated axons: Variable loss among fascicles

VvG stain
Differential fascicular involvement: Endoneurial supporting cells

ATPase pH 4.3 stain

Toluidine blue stain



Drawing from Wiegert-Pal stain
R. Cassirer (1910)

Leprous polyneuropathy with
differential fascicular loss of axons
Myelinated axon loss: Greater in some fascicles than others.



Neurofilament stain
Axon loss: Greater in some fascicles than others; Variable within fascicles.

Intrafascicular axon variation
Focal inflammation around a small endoneurial vessel (Left).
Localized loss of myelinated axons (red) around the vessel (Right).




Remak
Also see: Axon loss

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12/9/2013