 Gomori trichrome stain |
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Variable loss of myelinated (red) axons in the same nerve. Severe loss of myelinated axons in a fascicle on the left. More myelinated axons remain in an adjacent fascicle (right) |
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 Toluidine blue stain |
 Drawing from Wiegert-Pal stain R. Cassirer (1910) |
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Loss of myelinated axons is greater in some fascicles (left) than others (upper right). Subperineurial edema is present. |
Leprous polyneuropathy with differential fascicular loss of axons |
 Toluidine blue stain | |
This pattern of patchy axonal loss is associated with
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Focal inflammation around a small endoneurial vessel (Left). Loss of myelinated axons (red) around the vessel (Right). |