Small Vessel Pathology: Nerve

INFLAMMATION & SUBPERINEURIAL EDEMA

Inflammation Near a small epineurial vessel (Wide arrow) Subperineurial edema (Narrow arrow) In neighboring fascicle	Subperineurial edema (Low magnification; Arrows) Present to a variable degree in different fascicles

THICKENED VESSEL WALLS

Ultrastructure: From Robert E Schmidt MD	Ultrastructure: From Robert E Schmidt MD
Diabetes Vessel in Nerve Basal lamina space: Multiple layers	Non-diagnostic muscle biopsy Vessel in Muscle Thickened wall: Homogeneous

Basal lamina space of endoneurial vessels (Arrows): Thickened; Homogeneous Differential diagnosis Diabetes Chronic idiopathic axonal neuropathies CMT I Hypoxia M-protein related neuropathy Amyloid

Basal lamina space of endoneurial vessel (Arrow): Normal