Neuromuscular

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MONOCLONAL ANTIBODIES (M-proteins)

Monoclonal Gammopathies of Unknown Significance (MGUS)
  General characteristics
  General clinical features
  Specific associated clinical syndromes
  Testing

Neoplastic & Systemic Disorders
  Cryoglobulinemia
  IgG & IgA MGUS
  IgM MGUS
  Multiple myeloma
  Osteosclerotic myeloma
  Waldenström's macroglobulinemia

Monoclonal Gammopathies of Unknown Significance (& Other) 7


Neoplastic & Systemic Disorders


IgG & IgA MGUS

General
Nemaline rod myopathy
POEMS
Scleromyxedema




IgM MGUS
Waldenström's macroglobulinemia (Lymphoplasmacytoid lymphoma)
Cryoglobulinemia
Multiple Myeloma
Osteosclerotic myeloma

From M. Al-Lozi

Osteosclerotic myeloma
in patient with POEMS
  

Neuropathy with Amyloid-like depositis 9

International Myeloma Foundation
International Waldenstrom's Macroglobulinemia Foundation


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References

1. JNNP 1996;60:661-666, J PNS 2002;7:59-64
2.Clin Chem 1988;34:2196-2201; J Neurol Sci 1993;1209:93-98
3. NEJM 2002;346:564-569
4. Blood 2003;Online January
5. J Clin Oncol 2000;18:214-226
6. Br J Haematol 2005;129:776-783
7. N Engl J Med 2006;355:2765-2770
8. Neurology 2006;66:917918
9. J Peripher Nerv Syst 2012;17:182-190
10. Current Opinion Rheumatology 2014; Sep 11

11/11/2014