Neuromuscular

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ASYMMETRIC NEUROPATHIES

  • Many asymmetric sensory-motor neuropathies are treatable.
  • They are a major indication for biopsies of nerve and muscle.
CMAP from Falck

Mononeuritis Multiplex
Other asymmetric neuropathies Cytopathies

Also see: Asymmetric myopathies

Lymphoma 5

Lymphoma & Disease subtypes
  Angiotropic (Intravascular)
  Ataxia telangectasia
  Castleman disease
  CNS infiltration
  Hemophagocytic lymphohistiocytosis
  Hodgkin
  Non-Hodgkin
  Lymphoepithelial thymoma
  Lymphomatoid granulomatosis
  Monoclonal gammopathies (MGUS)
  PNS (Nerve) infiltration
    Widely metastatic disease
    Local
  Waldenström's macroglobulinemia
Lymphoma-related NM syndromes
  Cryoglobulinemia
  Paraneoplastic syndromes
    Motor
    Sensory
    Cerebellar: Tr; mGluR1
    Myelopathy, Necrotic
  Immune, Other nerve
    Amyloid
    IgM Antibody syndromes
      MAG; GM1; Sulfatide; GD1b
    POEMS
    Weak association
      CIDP (Varied lymphoma types)
      GBS (Hodgkin & CLL)
  Muscle & NMJ
    Myasthenia gravis
    Inflammatory myopathy
  Also see
    Diffuse infiltrative lymphocytosis syndrome (DILS)



Lymphoma Types
Infiltration of Nerve (Neurolymphomatosis)

Infiltrates primarily in spinal cord & CNS 1

Hodgkins Lymphoma

Non-Hodgkins Lymphoma

Lymphomatoid granulomatosis

Lymphoma-related syndromes: Other

Cholesterol emboli


Hemophilia A & B



Idiopathic Thrombocytopenic Purpura 6



Wartenberg's Migrant Sensory Neuritis 2



Sickle Cell Disease 4


Return to Polyneuropathy Index

References
1. Clinical Neurology and Neurosurgery 2000;101:275-279; JNNP 2001;71: 696-703
2. Muscle Nerve 2001;24:438-443
3. J Clin Neuromusc Dis 2001;3:63-69
4. Ann Neurol 2002;51:543–552
5. Muscle Nerve 2005;31:301–313, J Neurol Sci 2015; Jun 3
6. J Peripheral Nervous System 2007;12:286–289
7. European Journal of Neurology 2009;16:814–818

6/15/2015