Neuromuscular

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Myasthenia Gravis: Other associations

Associations
  AChR
  HLA
  PTPN22
  TNF
Other antibodies
Pregnancy
Striational antibodies
Systemic disorders
Thymus
  Size changes
  Thymoma
 
Thymoma in patient with Myasthenia Gravis
Chest X-ray: Right anterior mediastinal mass


Thymoma


Bell 1917


Thymoma (Anterior mediastinal mass)
in patient with Myasthenia Gravis
  

Thymic size changes


Anti-striational antibodies 16


Myasthenia Gravis: Other antibodies


Myasthenia Gravis & Systemic disorders


Acquired MG: Genetic Associations1, 2

AChR
HLA
PTPN22
TNF


    Familial recurrence risk

    Acetylcholine receptor

    HLA: Myasthenia Gravis associations 7


Other genes



HLA molecules

HLA disease associations
HLA-B27 Reiter's
Ankylosing spondylitis
HLA-DR4 Rheumatoid arthritis
Sjögren's syndrome
Giant Cell Arteritis
Lyme arthritis
HLA-DR3 SLE
Dermatomyositis
CREST
HLA-B8 Myasthenia Gravis
Grave's disease
Chronic active hepatitis
HLA-A3 Multiple sclerosis
Hemochromatosis


Return to Myasthenia

References
1. J Neuroimmunol 1996;65:125-131, Biomed Res Int 2013;2013:404053
2. J Autoimmunity 1997;10:407-413
3. Neurology 1999;52:447-452
4. Neurology 2001;57:1579-1582, Neurology 2002;59:9298
5. Neurology 2001;57:1555-1560
6. Eur J Haematol 2002;69:318320
7. J Autoimmunity 2003;21:105110
8. Neurology 2004;62:18941896, Arch Neurol 2000;57:527-531, Eur J Neurol 2007;14:617-620
9. Clin Cancer Res 2004;10:72707275
10. Rheumatology (Oxford) 2005; Sep 27
11. Proc Natl Acad Sci U S A. 2004;101:15464-15469
12. Genes Immun 2009 Aug 20
13. Journal of Neuroimmunology 2009; Online November
14. Ann Neurol 2010;67:726-738
15. J Neurol Sci 2011 Jan 12
16. Autoimmune Dis 2011;2011:740583
17. European Journal of Neurology 2012; Online Jan
18. Mult Scler 2011 Dec 19
19. Acta Neurol Scand 2012 Jun 23
20. J Neurol 2012;259:1290-1297
21. Hum Immunol 2013 Aug 7

1/3/2014