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Differential Diagnosis of Myasthenia Gravis

Fatigue (Ptosis): Familial MG

AUTOIMMUNE MG: Neonatal & Juvenile Forms

CHILDHOOD MYASTHENIA GRAVIS: TYPES
Neonatal
Transient
Recurrent
Arthrogryposis
Fetal AChR
Inactivation
Congenital Familial
Infantile
Acquired
Child
Maternal MG + + + - - -
Onset age 0 to 3 days
post natal
Congenital Congenital Birth Birth
to 1 year
> 1 year
More in Orientals
Weakness General General Face, Bulbar
Respiratory
Ocular
± General
Respiratory
General
Ocular
± General
Time course Remission
1 to 6 weeks
Static Improve
  over years
Fixed
  weakness
Fatal early, or
Improve > 2 years
Improve
  over years
Family history ± Other sibs
Mother
  Untreated
Other sibs
Mother
  Untreated
Other sibs
Mother
  Untreated
Often Usual Rare
Anti-AChR antibodies Most + vs
Fetal AChR
+ vs
Fetal AChR
- - 50% to 90%
More in Orientals



Myasthenia gravis: Neonatal Transient

Fetal acetylcholine receptor inactivation syndrome 3


Recurrent Congenital Arthrogryposis 1

Myasthenia gravis: Autoimmune, Childhood 2

Myasthenia Gravis: History

  • Original description: Thomas Willis

Thomas Willis 1621-1675

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References
1. Am J Med Genet 2000; 92:1-6
2. Neuromuscular Disorders 2011; Online Sept, J Neurol 2017 Mar 31
3. Neurol Neuroimmunol Neuroinflamm 2015;2:e57

4/4/2017