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Fatigue (Ptosis): Familial MG
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| CHILDHOOD MYASTHENIA GRAVIS: TYPES | |||||
| Neonatal | Congenital | Familial Infantile |
Acquired Juvenile |
Recurrent Arthrogryposis |
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| Maternal MG | + | - | - | - | + |
| Onset | 0 to 3 days post natal | Birth | Birth to 1 year | > 1 year More in Orientals |
Congenital |
| Weakness | Generalized | Ocular ± Generalized |
Respiratory Generalized | Ocular ± Generalized |
Generalized |
| Time course | Remission 1 to 6 weeks |
Fixed weakness | Fatal early, or Improvement > 2 years |
Improvement over years |
Static |
| Family history | ± Other sibs Mother Untreated |
Often | Usual | Rare | Other sibs Mother Untreated |
| Anti-AChR antibodies | Most | - | - | 50% More in Orientals |
+ vs Fetal AChR |
Myasthenia Gravis: History
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Thomas Willis 1621-1675
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