Neuromuscular

DENERVATION WITH REINNERVATION, CHRONIC INACTIVE

Muscle Fiber Type Grouping

  Associated with & Caused by: Axon regeneration


 

ATPase pH 9.4 stain

ATPase pH 9.4 stain

ATPase pH 9.4 stain

Normal: "Checkerboard"
pattern of type I (Light)
and II (Dark) fibers.
Chronic denervation
  Type I and type II muscle fibers are clustered in groups.
  Type II fibers in this biopsy are mostly type IIB (ATPase pH 4.6 stain, below right).

ATPase pH 4.3 stain

ATPase pH 4.6 stain

Fiber Type Grouping: Staining Patterns

ATPase pH 4.3 stain

Fiber type grouping: Incomplete fiber type switching (Varied fiber types in a single group)

ATPase pH 4.3 stain

Fiber type grouping with incomplete type switching: 2C fibers in clusters of grouped muscle fibers

ATPase pH 4.3 stain

Axon Loss


Toluidine blue stained plastic section

Nerve: Chronic Inactive Axon Loss (Denervation)

Also see: Ongoing or Active Denervation

Return to Neuromuscular Syndromes

9/12/2017