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SMA: General pathology SMA, Congenital (Type 0) SMA, Type 1 SMA, Type 2 Also see Spinal muscular atrophy XBSMA pathology |
![]() H&E stain |
![]() ATPase pH 9.4 stain |
| Grouped atrophy Small muscle fibers are often rounded Pyknotic nuclear clumps are not present. Large muscle fibers are hypertrophied. |
Large fibers: Hypertrophied & Type I Small fibers: Type I or II |
![]() H&E stain |
![]() H&E stain |
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Large grouped atrophy Clusters of large type I muscle fibers | |
![]() ATPase, pH 9.4 |
![]() ATPase, pH 9.4 |
| Small muscle fibers may be varied types (Left) or mostly type II (Right) | |
![]() ATPase, pH 4.3 |
![]() NADH |
| Many small fibers are type IIC | Small fibers stain darkly on NADH |
![]() H & E |
![]() H & E |
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Many muscle fibers are small. A few hypertrophied fibers are present | |
![]() H & E |
![]() H & E |
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Only small muscle fibers are present. Small fibers have moderate variation in size | |