Myopathy & Neuromuscular Junction       Disorders: Differential Diagnosis

DISTRIBUTION OF WEAKNESS		MUSCLE FEATURES	TIME COURSE	Vesalius 1543
General   Asymmetry   Distal ≥ Proximal     Hereditary   Face & Periocular     + EOM Weakness     No EOM Weakness   Limb-Girdle Focal   Congenital   Cranial     Bulbar     EOM     Ptosis     Tongue   Trunk     Diaphragm     Paraspinous     Posterior Neck     Respiratory     Scapula   Arms     Finger       Extension       Flexion     Proximal     Elbow flexor   Legs     Adductors     Hamstring     Quadriceps     Other muscles Weakness in most myopathies is   Symmetric   Proximal > Distal		Cramps Muscle Fiber Activity Muscle Size   Large Muscles   Weakness > Wasting   Wasting > Weakness   Absent Pain Tendon Reflexes Tremor MRI	Acute Episodic Fatigue   Myasthenia Onset of weakness   Congenital   Infantile Hereditary
SYSTEMIC FEATURES	LAB FEATURES	GENERAL TOPICS
Amyloid Cardiac   With Myopathy   No myopathy   Sudden Death CNS Endocrine Eye: Mitochondrial Gastro-Intestinal Hematology Infections Joint Contractures Myoglobinuria Neuropathy Paraneoplastic Renal Respiratory Failure Skeletal Skin	Autoantibodies Creatine Kinase (CK):   Very High   Unexpectedly High   Low Dystrophinopathy Glycogen Storage Immune & Inflammatory Inclusion bodies Ion Channel Disorders Lipid Disorders Mitochondrial Disorders Muscle biopsy useful Myofibrillar Myosin Disorders Pathology Protein degradation	Immunomodulating therapy Muscle innervation   Upper extremity   Lower extremity Neuromuscular Syndromes Sports Toxic Typical Disease Patterns Vitamins & Nutrition Gene Panels

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See Neuromuscular Syndromes Go to Differential Diagnosis of Neuropathies Return to Neuromuscular Home Page or newly revised Other revisions 2/14/2024