Anatomic definition
- Small-fiber neuropathies selectively involve
- Diagnosis
Small Fiber Neuropathy Features: Symptoms, Signs, Laboratory
7
- Sensory loss
- Modalities
- Patterns of distribution
- Length dependent: Earliest & most severe in distal legs
- Partial length dependent: Early & most severe in both hands & feet
- Non-length dependent: Early involvement in proximal & distal areas
- Insensitivity to pain
- Discomfort
- Other associated features
- Autonomic involvement
- Postganglionic unmyelinated small axons
- May occur without sensory features
- POTS
- Restless legs syndrome
- Unexpected Motor Features
- Cramps
17
- Fasciculations
- Myalgias
16
- Denervation: Intrinsic foot muscles
15
- Serum CK: Moderate elevation
- Serum antibodies
18
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Unmyelinated axons
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