Pathology features Inflammation Focal invasion Immune Cell types Endomysial inflammation Muscle fibers Aggregates Histochemistry AMPDA Amyloid-like Cytoplasmic bodies Eosinophilic Components αB-crystallin β-Amyloid Desmin LC3 p62 SMI-31 TDP-43 Ubiquitin VCP Ultrastructure Focal invasion MHC Class-1 expression Mitochondrial pathology Ultrastructure Myopathy Myonuclei Vacuoles Capillaries Variant syndromes IM-VAMP in HIV PM-Mito Ultrastructure Aggregates Focal invasion by cells Mitochondria Vacuoles |
![]() Gomori trichrome stain IBM (IM-VAMP): Myopathy; Inflammation; Aggregates & Vacuoles
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![]() H & E stain |
![]() H & E stain |
![]() H & E stain |
Myopathy: Chronic; Ongoing
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![]() Fiber size: Varied Focal invasion by cells Vacuoles |
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2C fibers (Intermediate-stained): Common ![]() ATPase pH 4.3 stain |
Alkaline phosphatase stain: Often normal ![]() Alkaline phosphatase stain |
![]() H&E stain |
![]() Acid phosphatase (Blue) stain |
![]() ![]() Gomori trichrome |
![]() Gomori trichrome |
![]() Congo red |
Inflammation: Endomysial & Perimysial Lymphocytes & Histiocytes in Endomysium Focal invasion of some muscle fibers by cells (Arrow) ![]() H & E stain |
Inflammation: Endomysial Focal invasion of some muscle fibers (Dark arrow) Partially fused (Split) muscle fiber (Light arrow) ![]() H & E stain |
![]() H & E stain |
![]() Esterase stain |
![]() Acid phosphatase stain |
![]() Acid phosphatase stain |
Focal invasion of muscle fibers
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![]() CD4 stain |
![]() CD3 stain |
![]() Acid phosphatase |
![]() Acid phosphatase |
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![]() VvG stain |
![]() CD4 CD4 cells: Present in foci & Scattered in endomysium |
![]() CD8 CD8 cells: More in foci than in other endomysial regions |
![]() CD8 stain CD8 cells: In endomysial cell foci in IM-VAMP |
![]() ![]() Congo red stain |
![]() Congo red stain |
![]() Congo red stain |
![]() Congo red stain |
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Vacuoles
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![]() Gomori trichrome stain |
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IBM: Vacuoles One, or several, in a muscle fiber Shapes: Irregular Some contain red-staining material ![]() |
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![]() Gomori trichrome stain |
![]() Gomori trichrome stain |
![]() Gomori trichrome stain Vacuoles & Cytoplasmic bodies Cytoplasmic bodies may occur in Muscle fibers that also have vacuoles Fibers near other fibers with vacuoles (Arrow) |
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![]() Gomori trichrome stain |
![]() Gomori trichrome stain |
![]() Gomori trichrome stain |
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![]() Congo red stain |
![]() Congo red stain |
![]() From: R. Schmidt |
![]() From: R. Schmidt |
![]() Alcian blue/Nuclear fast red |
Cytoplasmic Aggregates Dark, eosinophilic hyaline appearance (Arrows) |
Cytoplasmic Aggregate Large Near irregular vacuoles |
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![]() H&E stain |
![]() H&E stain |
![]() VvG stain |
![]() Gomori trichrome stain |
![]() Gomori trichrome stain |
![]() AMPDA stain |
![]() AMPDA stain |
![]() AMPDA stain |
![]() SMI-31 + Congo red stains |
![]() Congo Red + Fluorescence with Texas red filter |
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![]() SMI-31 + Congo red stains |
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![]() SMI-31 + Congo red stains |
![]() SMI-31 + Congo red stains |
SMI-31 staining in some nuclei![]() SMI-31 + Congo red stains |
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αB-crystallin
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Ubiquitin conjugates: IBM
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Valosin-containing protein (VCP): IBM
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![]() Congo red + β-amyloid stain |
![]() Congo red + fluorescence |
β-Amyloid: IBM
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![]() TDP-43 |
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![]() ![]() Congo red + TDP43 |
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TDP-43: IBM
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![]() ![]() Congo red + TDP43 |
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![]() CD4 (Green) + TDP43 (Red) TDP-43: Aggregates & Inflammatory cells in IBM
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![]() SMI-31 (Green) + TDP43 (Red) TDP-43: Aggregates and cytoplasmic staining with varied relation to SMI-31 staining
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![]() p62 stain |
![]() p62 stain |
![]() LC3 stain |
![]() LC3 stain |
![]() LC3 stain |
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![]() Congo red + LC3 stain |
![]() Desmin stain |
![]() Desmin stain |
Focal invasion of muscle fibers by cells Aggregates & Inclusions, Cytoplasmic |
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![]() From: R Schmidt |
![]() From: R Schmidt |
![]() From: R Schmidt |
![]() From: R Schmidt |
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![]() Normal |
![]() IBM |
![]() MHC Class I stain |
![]() MHC Class I stain |
![]() MHC Class I stain |
![]() H&E stain |
![]() Gomori trichrome stain |
![]() Gomori trichrome stain |
![]() Congo red stain |
![]() H&E stain |
![]() H&E stain |
![]() H&E stain |
![]() H&E stain |
![]() H&E stain |
Cytochrome oxidase (COX): Some patients have scattered COX- muscle fibers ![]() Cytochrome oxidase stain |
![]() COX stain |
![]() SDH stain |
![]() SDH stain |
![]() From: R Schmidt |
![]() From: R Schmidt |
![]() From: R Schmidt |
![]() From: R Schmidt |
![]() From: R Schmidt |
![]() From: R Schmidt |
![]() From: R Schmidt |
![]() From: R Schmidt |
![]() From: R Schmidt |
![]() VvG stain |
![]() VvG stain |
![]() Ulex stain |
![]() Ulex stain |
![]() From: R Schmidt |
![]() From: R Schmidt |
![]() From: R Schmidt |