IM-VAMP during HIV
Fiber size: Varied
Small muscle fibers: Angular or Round
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmhelp.jpg)
H&E stain
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![](../pics/biopsy/inflammation/ibm/hivibm/hivibmreg.jpg)
H&E stain
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IM-VAMP during HIV: Myopathy + Capillary pathology
Muscle fibers
Size: Varied
Small muscle fibers: Angular or Round
Internal nuclei
Immaturity in some fibers: Cytoplasm basophilic; Nuclei large
Endomysial connective tissue: Increased
Endomysial capillaries: Large
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmmyophehp.jpg)
H&E stain
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![](../pics/biopsy/inflammation/ibm/hivibm/hivibmcapsgthp.jpg)
Gomori trichrome stain
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IM-VAMP during HIV
Internal architecture: Coarse in many muscle fibers
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmnadhlp.jpg)
NADH stain
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![](../pics/biopsy/inflammation/ibm/hivibm/hivibmcrlp.jpg)
Congo red stain
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IM-VAMP during HIV
Inflammation: Endomysial
![](../pics/biopsy/inflammation/ibm/hivibm/hivibminflamhehp.jpg)
H&E stain
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![](../pics/biopsy/inflammation/ibm/hivibm/hivibmfocinv.jpg)
H&E stain
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IM-VAMP during HIV
Inflammation
Endomysial
Focal invasion of muscle fibers
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmfocinvcrhp.jpg)
Congo red stain
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![](../pics/biopsy/inflammation/ibm/hivibm/hivibmfocinvcrhp2.jpg)
Congo red stain
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IM-VAMP during HIV
Inflammation
Focal invasion of muscle fibers
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmacp.jpg)
Acid phosphatase stain
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![](../pics/biopsy/inflammation/ibm/hivibm/hivibmcd4.jpg)
CD4 stain
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IM-VAMP during HIV
Inflammation, endomysial
Composed of CD4 & CD8 lymphocytes
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmcd8lp.jpg)
CD8 stain
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![](../pics/biopsy/inflammation/ibm/hivibm/hivibmcd8hp.jpg)
CD8 stain
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IM-VAMP during HIV
MHC Class I upregulation on surface of muscle fibers
MHC Class I is also upregulatied in the cytoplasm of some muscle fibers
Endomysial lymphocytes also express MHC Class I
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmmhc1lp.jpg)
MHC Class I stain
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![](../pics/biopsy/inflammation/ibm/hivibm/hivibmvachehp.jpg)
H&E stain
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IM-VAMP during HIV
Irregular vacuoles in some muscle fibers
Some vacuoles have reddish border on Gomori trichrome stain
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmvacgthp.jpg)
Gomori trichrome stain
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IM-VAMP during HIV: Aggregates
Cytoplasmic bodies in muscle fibers
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmcbgthp.jpg)
Gomori trichrome stain
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IM-VAMP during HIV
AMPDA aggregates in some muscle fibers
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmampdahp.jpg)
AMPDA stain
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IM-VAMP during HIV
LC3 aggregates in some muscle fibers
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmlc3hp.jpg)
LC3 stain
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IM-VAMP during HIV: Mitochondrial pathology
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmsdhlp.jpg)
Succinate Dehydrogenase (SDH) stain
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SDH-positive muscle fibers: Scattered
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmsdhhp.jpg)
Succinate Dehydrogenase (SDH) stain
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COX negative muscle fibers: Scattered
![](../pics/biopsy/inflammation/ibm/hivibm/hivibmcoxhp.jpg)
Cytochrome oxidase (COX) stain
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1/18/2021