Neuromuscular

Capillary Pathology: Muscle

ELS in BIM
Minimal Myopathy
Systemic Sclerosis + Myopathy
Regional microvasculopathies
  Dermatomyopathy syndromes
Also see
  Capillary pathology
  Pipestem capillaries

Capillary Pathology with Minimal Myopathy


H&E stain
Endomysial Capillaries (Arrow)
  Moderately enlarged
Muscle fibers
  Fiber sizes: Moderately varied

H&E stain

Gomori trichrome stain
Endomysial Capillaries
  Moderately enlarged
  Some have thick basal lamina

Gomori trichrome stain
Endomysial Capillaries
  Moderately enlarged

Congo red stain

VvG stain

ATPase pH 4.3 stain
Endomysial Capillaries
  ATPase positive (Arrow)

ATPase pH 4.3 stain

NADH stain
Endomysial Capillaries
  NADH positive

NADH stain

NADH stain

Acid phosphatase stain
Endomysial Capillaries
  Acid -phosphatase: Mild staining
  Neighboring histiocytes (Arrow)

Acid phosphatase stain
Endomysial Capillaries
  PAS stains capillary basal lamina

PAS stain
Endomysial Capillaries: Basal Lamina
  Irregular increase in basal lamina layers around capillaries (Arrows)
Capillary Basal Lamina: Multiple circumferential layers

Systemic Sclerosis: Capillary Pathology + Myopathy


H&E stain
Myopathy
  Muscle Fiber sizes: Varied
  Small, Immatur fibers: Scattered
Endomysial Capillary Pathology
  Capillary sizes: Large
  Capillary basal lamina: Thick
  Endothelial cells: Large in enlarged capillaries

Gomori trichrome stain

VvG stain
Myopathy
  Muscle Fiber sizes: Varied
  Small, Immatur fibers: Scattered
Endomysial Capillary Pathology
  Capillary sizes: Large
  Capillary basal lamina: Thick
  Endothelial cells: Large in enlarged capillaries

VvG stain

VvG stain
Endomysial Capillary Pathology
  Capillary sizes: Large
  Capillary basal lamina: Thick
  Endothelial cells: Large in enlarged capillaries

Congo red stain

NADH stain
Endomysial Capillary Pathology
  Capillary sizes: Large
  Capillary basal lamina: Thick
  Endothelial cells: Large; NADH positive

ATPase pH 4.3 stain
Endomysial Capillaries
  Endothelial cells: ATPase positive
  Capillary basal lamina: Often thick around endothelial cells

ATPase pH 4.3 stain

ATPase pH 4.3 stain
Endomysial Capillaries
  Endothelial cells: Acid phosphatase positive

Acid phosphatase stain

UEA I stain
Endomysial Capillaries
  Size: Often large
  Endothelial cells
    Stain for UEAI
    Enlarged inside thick basal lamina
  Basal lamina (Unstained): Thick

MHC I stain
Endomysial Capillaries
  Size: Often large
  Endothelial cells
    Stain for MHC Class I
    Enlarged inside thick basal lamina
  Basal lamina (Unstained): Thick

MHC I stain
Systemic Sclerosis: Myopathy
  Muscle fibers
    Varied sizes
    MHC1: Patchy upregulation

MHC Class I stain
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12/11/2021