HNRNPA2B1 Myopathy: IBMPFD2
|
Aggregates Myopathy Vacuoles |
 H&E stain |
Muscle fibers
Sizes: Varied
Small fibers
Round > Elongated
May occur in clusters
Internal nuclei
Endomysial connective tissue: Increased with disease progression
 H&E stain |
Myopathy
Muscle fibers
Sizes: Varied
Small vacuoles
 H&E stain |
 NADH stain |
Muscle fibers
Sizes: Varied
Small fibers: Dark stained
Necrosis: Rare
 NADH stain |
 Gomori trichrome stain |
Muscle fibers
Sizes: Varied
Internal nuclei
Small fibers: Dark, irregular cytoplasm
 VvG stain |
 Acid phosphatase stain |
Acid phosphatase stains cytoplasm or cytoplasmic granules in some fibers
 Acid phosphatase stain |
Myopathy: Fibers with abnormal distribution of myonuclei
 H&E stain |
Necrosis: Few scattered muscle fibers
 H&E stain |
 Gomori trichrome stain |
 Acid phosphatase stain |
 AMPDA stain |
HNRNPA2B1: Vacuoles
 H&E stain |
 H&E stain |
 H&E stain |
 VvG stain |
 Gomori trichrome stain |
 Gomori trichrome stain |
 AMPDA stain |
 AMPDA stain |
 Congo red stain |
 Congo red stain |
 Congo red stain |
 ATPase pH 4.3 stain |
HNRNPA2B1: Aggregates
 AMPDA stain |
 AMPDA stain |
 AMPDA stain |
 LC3 stain |
 SMI31 stain |
 Desmin stain |
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4/26/2021