Neuromuscular

Immune Myopathies with Perimysial Pathology (IMPP): OJ antibody associated 1

Perimysial connective tissue pathology
  Histiocytic cells
  Structure damage
Muscle fiber pathology
  Necrosis & Regeneration
  MHC I
  Aggregates
Also see
  IMPP
  Dermatomyositis: Adult, IMPP type
  Jo-1 muscle pathology



H&E stain
Perimysial pathology
Muscle Fiber Pathology

H&E stain

OJ antibodies: Perimysial pathology

Esterase stain

Esterase stain

Acid phosphatase
Perimysial Cells: Histiocytic

H&E stain

HAM56 stain


Gomori trichrome stain
Perimysium Structure

H&E stain

VvG stain

VvG stain

OJ-antibody related myopathy: Perimysial pathology
  Alkaline phosphatase stains
    Perimysial connective tissue
    Cytoplasm of many neighboring, small regenerating, muscle fibers

Alkaline phosphatase

OJ-antibody related myopathy: Muscle fibers

MHC Class I stain
Muscle Fiber Pathology

C5b-9 stain

C5b-9 stain
OJ antibodies: Necrotic muscle fibers tend to be located near the edges of fascicles

H&E stain

VvG stain
OJ antibodies: Necrotic & Regenerating muscle fibers tend to be located near the edges of fascicles

OJ-antibody related myopathy: Muscle fiber aggregates

VvG stain
Muscle fiber Aggregates
  Location: Cytoplasm
  Stain for: LC3; VvG

LC3 stain

LC3 stain

Capillaries
  Staining by ATPase

ATPase pH 4.3 stain

Return to Inflammatory myopathies
Return to IMPP

References
1. Brain Pathol 2023 Mar 7:e13155

3/20/2023