Neuromuscular

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TACHYKININS: SUBSTANCE P & NEUROKININS A AND B

General

Transmitters
Precursors: Preprotachykinins
Synthesizing enzymes: Peptidases
Metabolizing enzymes:
Metabolite: Peptide fragments
Receptors
Receptor subtypes AgonistsAntagonistsSecond messenger
NK(1) SPOMe, GR 73632,
Sar9Met(O2)11SP;
Substance P
GR82334, RP67580,
CP-99994
PI; G-protein
NK(2) GR 64349;
Neurokinin A
L-659877, SR48968,
MEN10207, GR94800
GR100679
PI; G-protein
NK(3) Senktide;
Neurokinin B
GR138676 PI




NK1 (Substance P) Receptor



Bradykinin



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12/10/2007