Internal architecture: Linear (White arrow) & less punctate compared to control muscle fibers (Dark arrow)
Linearization of Internal architecture: More severe
Dark streaks of NADH staining in paler (Type 2) muscle fibers
Linearization of internal architecture
Mostly in paler fibers
One small dartk muscle fiber is a pyknotic nuclear clump (from denervation without reinnervation
Linearization of Internal architecture: Other stains
Linearization: Visible as cracks in type 2 (Darker stained) muscle fibers
ATPase pH 9.4 stain
Linearization: Visible as black-stained linear regions in muscle fibers
VvG stain
Motheaten muscle fibers
NADH stain
Lobulated Muscle Fibers
Abnormal internal architecture: Moth-eaten & Lobulated muscle fibers
Dark, irregularly stained fibers are: Moth-eaten, Lobulated or Trabecular
More common in type 1 muscle fibers
May occur in myopathy or neuropathy.
Myopathies commonly with lobulated fibers: LGMD 2A;
Ullrich CMD; Bethlem myopathy
NADH stain
Lobulated Muscle Fibers: Patient with cachexia & muscle fiber atrophy
