Ring fibers (Ringbinden; Spiral Annulets) & Sarcomere disorientation

NADH stain

H&E stain

Congo red stain
Ring fibers
  • Staining
    • NADH & AMPDA stains: Ring of striations, perpendicular to normal orientation, around circumference of muscle fiber
    • H & E stain: Internal, ring-shaped, dark-staining regions in small fibers
    • Congo red: "Amorphous" ring in a muscle fiber with paler central region
  • Clinical correlations
    • Poorly defined
    • Associated disorders

NADH stain

AMPDA stain

NADH stain
  • Dark staining sarcoplasmic pad around rim of fiber (Right)

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