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Muscle fibers: Regeneration

Human   Myopathic grouping Mouse

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H&E stain

Regenerating muscle fibers
  Size: Small
  Cytoplasm: Basophilic
  Nuclei: Large
  Scattered

H&E stain

H&E stain

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Gomori trichrome stain

Gomori trichrome stain

Immature (Regenerated) muscle fibers: Coarse internal architecture

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NADH stain

NADH stain

Regenerating muscle fibers: Coarse, Darker-stained, internal architecture; Intermediate-sized

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ATPase pH 4.3 stain

Immature (Regenerated) muscle fibers: Type 2C (Intermediate-stained)

ATPase pH 4.3 stain

ATPase pH 4.3 stain

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Acid phosphatase stain

Regenerating muscle fibers: Neighboring endomysial acid phosphatase cells near capillaries

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Regenerated Muscle Fibers: Mouse

Nuclei in regenerated muscle fibers in mice often remain in central regions of muscle fibers
Pathology cause: 1 week after injection of cardiotoxin into mouse muscle
Histology
  Many muscle fibers have central nuclei
  Regenerated muscle fibers are smaller than normal at this stage
  Regeneration after muscle fiber necrosis is less complete in region on right

H&E stain From S Moliere

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1/8/2023