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Normal adult Normal child Immature muscle fibers Linearization Moth-eaten fibers Lobulated fibers Ring fibers Target fibers Denervated: Small angular fibers Trabecular myopathy |
 Normal internal architecture Muscle fibers in an adult |
 Normal internal architecture Muscle fibers in a child Staining pattern is coarser than in adults |
 Immature (regenerating) muscle fibers Staining pattern is coarser than in normal fibers in adults |
 Linearization of membranes in pale fibers Non-specific change. Common in myophosphorylase deficiency. |
 Abnormal internal architecture Darkly stained fibers are moth-eaten. Moth-eaten fibers may occur in myopathy or neuropathy. |
 Abnormal internal architecture Darkly stained fibers are lobulated Lobulated fibers may occur in myopathy or neuropathy Myopathies commonly with lobulated fibers: LGMD 2A; Ullrich CMD; Bethlem myopathy |
 "Trabecular" myopathy Staining pattern is similar to lobular muscle fibers Occasional ring fibers are present |