Neuromuscular

CENTRAL CORE DISEASE: Pathology


H&E stain
Adult

H&E stain
Adult

Gomori trichrome stain
Adult
 

H&E stain
Child
Myopathic changes in central core disease
  • Fiber size: Variability
  • Connective tissue: Increased
  • Internal nuclei

Cores

  • Central clear zone ("core") in muscle fibers
    • NADH stain: Reduced
    • Cores run whole length of muscle fibers

NADH stain

ATPase, pH 9.4
Muscle fiber types

Marked type I muscle fiber predominence
Some cores have loss of central myofibrillar structure


SDH stain

PAS stain
Mitochondria

Not present in cores

Glycogen

No glycogen in cores



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3/30/2005