CENTRAL CORE DISEASE: Pathology

H&E stain Adult	H&E stain Adult	Gomori trichrome stain Adult
	H&E stain Child
Myopathic changes in central core disease Fiber size: Variability Connective tissue: Increased Internal nuclei

Cores Central clear zone ("core") in muscle fibers NADH stain: Reduced Cores run whole length of muscle fibers
NADH stain

ATPase, pH 9.4

Muscle fiber types Marked type I muscle fiber predominence Some cores have loss of central myofibrillar structure

SDH stain	PAS stain
Mitochondria Not present in cores	Glycogen No glycogen in cores