Neuromuscular

TUBULAR AGGREGATES

Tubular aggregates: Pathology Differential Diagnosis



H & E stain
Muscle fibers
  Pink cytoplasmic areas: May contain nuclei
  Irregular-shaped clear regions

H & E stain

Congo red stain


Gomori trichrome stain


Tubular aggregates
  Stain red on Gomori trichrome

Gomori trichrome stain


Gomori trichrome stain
Tubular aggregates: May have elongated or rounded shapes

Gomori trichrome stain

Gomori trichrome stain


VvG stain

Tubular aggregates
  Stain gray-black on VvG


NADH-TR reductase (NADH) stain



Tubular aggregates:
  Stain dark on NADH

NADH stain


AMPDA stain
Tubular aggregates: Contain AMPDA

AMPDA stain


ATPase pH 9.4 stain
Tubular aggregates (Pale regions): Are often more common in type 2 muscle fibers

ATPase pH 4.3 stain


Sudan black stain
Tubular aggregates: Stain for lipid on Sudan black

Sudan black stain

Tubular aggregates
  May have mild or patchy staining for Acid Phosphatase

Acid Phosphatase stain

Tubular aggregates: Ultrastructure; 3 types


From T Mozaffar

Return to Myopathies with tubular aggregates

References
1. J Neuropathol Exp Neurol 2016;75:1171-1178


12/14/2016