Neuromuscular

PERIPHERAL NERVE: Active Demyelination 1,2


Electron micrographs: From Robert Schmidt MD
Demyelinated axons (Arrows)
Axons, without myelin, surrounded by phagocytic cells.
Axon cytoplasm is dark, containing closely spaced neurofilaments.
Phagocytic cells contain lipid droplets & inclusions.
See: AIDP


Electron micrograph: From Robert Schmidt MD
Myelin stripping, Macrophage mediated
Phagocytic cell process (Arrow): Extends beneath a layer of myelin.
See: AIDP

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References
1. Neurology 2018;91:1051-1060
2. J Neurol Neurosurg Psychiatry 2020;9:650-659

9/26/2022