Denervated Schwann Cells
Büngner bands
Linear bands of interdigitating Schwann cells
Surrounded by basal lamina (Schwann tube)
Size: > 3 μm
Molecular cell marker: P0 protein
No associated axons
Basement membrane: Irregular
Due to
Loss of Myelinated axons
Proliferation of associated Schwann cells
Axon regeneration: Often occurs within Büngner bands
Course with no axon regeneration
Schwann cells
Atrophy
May develop characteristics of perineurial cells
Pinocytotic vesicles
Divide endoneurium into microfascicles
Denervated
: Also present in
onion bulbs
Difference from non-myelinating Schwann cells:
Contain P
0
Collagen accumulates
Collagen fibers
May surround Schwann cell tube
Thinner (23 to 30 μM than normal endoneurial collagen
Collagen Pockets
Due to loss of: Unmyelinated axons
Non-myelinating Schwann cells (Remak cells) surround: Collagen fibrils
Proliferation of Remak cells: Response to degeneration of myelinated axons
From: R E Schmidt MD
Bands of Büngner:
Large Denervated
Schwann Cell Bands
Denervated Schwann cells: Have normal Basal lamina outside surface membrane
Small & Large Axon loss: Severe
Neurofilaments (Green); P0 (Red)
Büngner Bands stain for P0 protein
: In absence of myelin (Below)
Axon loss
: No staining for large or small axons (Green)
Loss of all myelinated axons
VvG stain
Loss of all axons
Neurofilament + Gomori stain
Non-Myelinating Schwann cells
(NCAM stain): Remain present all through endoneurium
NCAM + Gomori
Collagen pockets
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Axonal loss
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3/21/2017
