Proliferation of Remak cells: Response to degeneration of myelinated axons
Büngner Bands
Bands of Büngner: Large Denervated Schwann Cell Bands
From: R E Schmidt MD
Denervated Schwann cells: Have normal Basal lamina outside surface membrane
Büngner Band Cells: Schwann cells with no associated axon
Small & Large Axon loss: Severe
Neurofilaments (Green); P0 (Red)
Büngner Bands stain for P0 protein: In absence of myelin (Below) Axon loss: No staining for large or small axons (Green) Büngner bands
p0 and NCAM co-localize in Schwann cells with no associated axons (Yellow)
Small NCAM positive cells (Green) are associuated with remaining small, unmyelinated axons Normal: Many p0 positive myelin sheaths with no NCAM
NCAM (Green) & p0 (Red) stains
Loss of all myelinated axons
VvG stain
Loss of all axons
Neurofilament + Gomori stain
Non-Myelinating Schwann cells (NCAM stain): Remain present all through endoneurium
