  H & E stain |
|
|
Cytoplasmic bodies in desmin myopathy: Hyaline eosinophilic appearance on H &: E stain. Internal nuclei are common in some patients. |
|
 Gomori trichrome stain |
|
 Gomori trichrome stain |
|
|
Desmin myopathy: Dark stained regions within muscle fibers. |
|
 NADH stain Sarcoplasmic membranes are absent from regions with desmin-containing cytoplasmic bodies. Irregular (moth-eaten) internal architecture is present in several muscle fibers |
|
 ATPase, pH 9.4 Myofibrillar apparatus is absent from regions with desmin-containing cytoplasmic bodies |
|
  Anti-desmin antibody |
|
|
|
|
|
|
Myofibrillar (desmin) myopathy Cytoplasmic accumulations of material that stains darkly with anti-desmin antibodies. Small, regenerating muscle fibers also show abundant, but more diffuse, cytoplasmic desmin. |
|