Neuromuscular

Home, Search, Index, Links, Pathology, Molecules, Syndromes,
Muscle, NMJ, Nerve, Spinal, Ataxia, Antibody & Biopsy, Patient Info


PORPHYRIA1

General
  Acute
  Biochemistry
  Genetics
Unsafe drugs

Acute intermittent porphyria
Coproporphyria
Variegate Porphyria
δ-aminolevulinic acid dehydratase deficiency

Biochemistry: General


Genetics: General


Acute porphyrias: General


Acute Intermittent Porphyria

  Porphobilinogen deaminase (Hydroxymethylbilane synthase; HMBS) ; Chromosome 11q23.3; Dominant

Coproporphyria

  Coproporphyrinogen 3 oxidase (CPOX) ; Chromosome 3q11.2; Dominant

Variegate Porphyria

  Protoporphyrinogen oxidase (PPOX) ; Chromosome 1q23.3; Dominant

Porphyria, Acute hepatic

  δ-aminolevulinate dehydratase (ALAD; PBGS) Chromosome 9q32; Recessive
PORPHYRIAS: UNSAFE DRUGS
Strong evidence Probably or Possibly unsafe
Androgens
Barbiturates
Estrogens
Ethanol
Griseofulvin
Hydantoins
Progesterones
Sulfonamides
Alkylkating agents
Aminophylline
Bemegride
Benzodiazepines
Bromobenzine
Carbamazepine
Chloramphenicol
Chlorpropamide
Clonidine
Chloroquine
Danazol
Dapsone
Disopyramide
Enflurane
Ergotamine
Etomidate
Eucalyptol
Glutethimide
Halothane
Hydralazine
Imipramine
Ketamine
Ketoconazole
Mepivacaine
Meprobamate
Methsuximide
Methyldopa
Metronidazole
Metyrapone
Miconazole
Nalidixic acid
Nifedipine
Nikethamide
Nitrazepam
Nortriptyline
Pentazocine
Phenazone
Phenoxybenzamine
Phensuxamide
Phenylbutazone
Primidone
Pyrazinamide
Rifampin
Spironolactone
Succinimides
Theophylline
Tolazemide
Tolbutamide
Trimethadone
Troxidone
Valproate
Verapamil


External links: Porphyria-Europe; Porphyria
Return to Motor Neuropathies
Return to Neuromuscular home page

References

1. Lancet 2005;365:241252

3/22/2012