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Gangliosides, Glycolipids & related Saccharides

Disorders
  Antibody related
  Hereditary
Organisms
Structures


GLYCOLIPID STRUCTURES 
                Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1'Ceramide
                                  3
                                  |
                           Neu5Acα2
 GM1 ganglioside 
                Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1'Ceramide
                 3
                 |
          Neu5Acα2
 GM1b ganglioside 
                Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1'Ceramide
 asialo-GM1 (GA1) 
                       GalNAcβ1-4Galβ1-4Glcβ1-1'Ceramide
                                  3
                                  |
                           Neu5Acα2
 GM2 ganglioside 
      GalNAcβ1-4Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1'Ceramide
                 3                3
                 |                |
          Neu5Acα2         Neu5Acα2
 GalNAc-GD1a ganglioside 
                Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1'Ceramide
                 3                3
                 |                |
          Neu5Acα2         Neu5Acα2
 GD1a ganglioside 
                Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1'Ceramide
                                  3
                                  |
                 Neu5Acα2-8Neu5Acα2
 GD1b ganglioside 
                Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1'Ceramide
                 3                3
                 |                |
Neu5Acα2-8Neu5Acα2                |
                           Neu5Acα2
 GT1a ganglioside 
                Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1'Ceramide
                 3                3
                 |                |
          Neu5Acα2                |
                 Neu5Acα2-8Neu5Acα2
 GT1b ganglioside 
                Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1'Ceramide
                 3                3
                 |                |
Neu5Acα2-8Neu5Acα2                |
                 Neu5Acα2-8Neu5Acα2
 GQ1b ganglioside 
                                   SO4-3Galβ1-1'Ceramide
 Sulfatide 
   SO4-3GlcAβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-1'Ceramide
 SGPG 
   SO4-3GlcAβ1-3Galβ1-4GlcNAcβ1-2Manα1
                                     |
                                     6
                           GlcNAcβ1-4Manβ1-4GlcNAcβ1-4GlcNAc-
                                     3                6
                                     |                |
                       GlcNAcβ1-2Manα1            Fucα1
 P0 & PMP-22 oligosaccharides1 
                Galβ1-4GlcNAcβ1-2Man-O-Ser/Thr
                 3     
                 |    
          Neu5Acα2
α-Dystroglycan
    O-mannosylated oligosaccharides in muscle & brain
IdoA-2S-GlcNS-6S
Trisulfated Heparin Disaccharide (TS-HDS)

Glycolipid-like structures on neuropathy-associated microorganisms2

Microorganism Glycolipid-like structure
Campylobacter jejuni GM1, GM1b, GD1a, GalNAc-GD1a GD3, GT1a, GQ1b
Haemophilus influenzae GM1, GT1a
Mycoplasma pneumoniae Galactocerebroside
Cytomegalovirus GM2



Antibodies to glycolipid- & glycoprotein-related saccharides: Related disorders

Neuropathy syndrome Antibody target Antibody isotype
Chronic
Sensory-Motor
Demyelinating
 		Myelin-associated glycoprotein (MAG)
Other: SGPG, SGLPG		 IgM (monoclonal)
Chronic ataxic neuropathy GD1b, GD2, GD3, GT1b, GQ1b IgM (monoclonal)
Motor neuropathy GM1, GalNAc-GD1a, NS6S IgM (polyclonal or monoclonal)
Sensory neuropathy, small fiber TS-HDS IgM (monoclonal)
Sensory neuropathy Sulfatide IgM (monoclonal or polyclonal)
Acute motor axonal neuropathy GM1, GM1b, GD1a, GalNAc-GD1a IgG
Miller Fisher syndrome
Bickerstaff’s brainstem encephalitis
Acute ophthalmoparesis
Ataxic Guillain–Barré syndrome
 GQ1b, GT1a IgG
Pharyngeal–cervical–brachial weakness GT1a (GQ1b) IgG


External links
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References
1. J Neurochem 2000;75:853-860
2. Brain 2003;125:2591-2625

6/23/2018