Neuromuscular

DISUSE ATROPHY, SEVERE


Muscle fiber atrophy

All muscle fibers are small

H&E stain

Small Muscle Fibers
  Shapes: Varied
  Surface: Irregular
  Nuclei: Large; Pale

H&E stain


H&E stain
Small Muscle Fibers
  Shapes: Varied
  Surface: Irregular
  Nuclei: Large; Pale
  Sizes: Varied

H&E stain


Congo red stain
Small Muscle Fibers
  Shapes: Varied
  Surface: Irregular
  Nuclei: Large; Pale
  Sizes: Varied

Congo red stain


VvG stain
Small Muscle Fibers
  Shapes: Varied
  Surface: Irregular
  Nuclei: Large; Pale
  Sizes: Varied
  Internal architecture: Variable; Coarse

VvG stain

Disuse atrophy
  Smallest muscle fibers: Type 2 (Dark)

ATPase pH 9.4 stain

Disuse atrophy
  Internal architecture: Moderately coarse
  Smallest muscle fibers: Intermediate stained

NADH stain

Disuse atrophy
  Clustered lipofuscin granules

Acid phosphatase stain

See
  Fiber type disorders
  Fiber type properties

Return to Neuromuscular Home Page
Return to Myopathies with wasting

References
1. Am J Physiol Cell Physiol 2012; Online August

7/11/2016