Neuromuscular

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GLUTAMATE (& ASPARTATE)

Transmitters
Precursors: None
Synthesizing enzymes: None
Inactivation: Reuptake
Glutamate transaminase
Metabolite: Glutamine
Receptors
Receptor types AgonistsAntagonistsSecond messenger
NMDA NMDA, CPP,
trans-2,3-PDA,
(-)-cis-1-ACPD
CGP37849
MK801: Channel blocker;
PCP: Non-competitive
AP5 & AP7
Ca++
Mg++: Voltage sensitive
Glycine: Regulatory
AMPA: 1 ;
2 ; 3 ; 4
AMPA,
Quisqualate
NBQX, CNQX
DNQX
Cation conductance
Kainate Kainate,
Domoate
NBQX, CNQX
DNQX
Cation conductance
Metabotropic 1S,3R-ACPD,
Ibotenate
None PI; G-protein





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9/15/2003