Neuromuscular

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Features of motor syndromes: Likely response to therapy

Clinical Pattern
of Weakness		 Motor
Conduction Block		 Other Evidence
of Demyelination		 Serum IgM vs
GM1 Ganglioside
or NS-6S		 Therapy Evidence for
Rx Efficacy
Distal Asymmetric + + or - + Cyclophosphamide
Immune Globulin
Rituximab
Not Prednisone		 Strong
Distal Asymmetric - - + Cyclophosphamide
Rituximab		 Moderate
Distal Asymmetric + + or - - Cyclophosphamide
IVIg		 Moderate
r/o CIDP
Distal Asymmetric - + + or - Cyclophosphamide
? IVIg
 Moderate
Distal Asymmetric - - - ? None
Proximal - - - ? None
UMN Signs + or - + or - + or - ? None

Go to Cyclophosphamide Treatment Protocol
Go to Motor Neuropathies & Anti-GM1 Antibodies
Go to Rituxan treatment protocol
Go to Demyelinating Neuropathies (MMN)
Return to Motor Syndromes

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5/10/2012