---

Myelin, Uncompacted

Definition: Non-fusion of inner aspects of Schwann cell membranes
All images from patients with POEMS syndrome
Compare to:
  Myelin wide spacing: 1; 2

---

Uncompacted Myelin: Outer Myelin Layers

From: RE Schmidt

Uncompacted Myelin
  Layers of double membranes

From: RE Schmidt

---

Uncompacted Myelin: Inner Myelin Layers

From: RE Schmidt

Uncompacted Myelin
  Layers of double membranes

From: RE Schmidt

From: RE Schmidt

Uncompacted Myelin
  Layers of double membranes

From: RE Schmidt

From: RE Schmidt

---

Uncompacted Myelin: Internal or All Myelin Layers

From: RE Schmidt

Uncompacted Myelin
  Layers of double membranes

From: RE Schmidt

From: RE Schmidt

Uncompacted Myelin
  Layers of double membranes

From: RE Schmidt

---

From: RE Schmidt

---

Myelin pathology: Same nerve as Myelin Uncompaction

From: RE Schmidt

Schwann cell cytoplasm
  Contains Pi granules

---

From: RE Schmidt

Myelin: Abnormal Folding

---

From: RE Schmidt

Myelin Ovoid

---

Myelin Structure: Irregular

  Regions of myelin have MBP without P0 (Red)

P0 = Green; Myelin Basic Protein (MBP) = Red; Costain = Yellow

---

Axon Atrophy

  Axons in MBP stained myelin sheaths appear smaller than normal
  See: Control

Neurofilament = Green; Myelin Basic Protein (MBP) = Red; Costain = Yellow

---

Axon Atrophy

  Many Myelinated axons (Green, no associated NCAM) are small

Neurofilament = Green; NCAM = Red; Costain = Yellow

---

Return to: Neuromuscular
Return to: POEMS

References

7/4/2024