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Anti-Nuclear (ANA; HEp-2 IFA) & Cytoplasmic Antibody: Staining Patterns

	ANA Pattern	Antigens	Diagnosis	Images
Nuclear	Homogeneous	dsDNA Nucleosomes Histones	SLE Hepatitis Juvenile arthritis	HEp-2 cell IIF
	Speckled	Scl70 Sm U1RNP U4/U6RNP U5RNP U11/12RNP RNA Pol III Ku antibody RuvBl 1/2	SLE SSc MCTD	HEp-2 cell IIF
	Fine Speckled	SS-A/Ro SS-B/La Mi-2 TIF1-γ & -β Ku	Systemic Sclerosis Dermatomyopathy
	Nucleolar	PM/Scl Th/To Fibrillarin	SSc BCIM	HEp-2 cell IIF
	Dots	SMN p80-coilin	None
	Multiple Dots	Sp-100 PML proteins MJ/NXP-2	Dermatomyopathy
	Centromere	Centromere CENP-B	SSc: Limited   Cutaneous
Cytoplasmic	Fine Speckled	RuvBL 1/2 eiF2b PL7 PL12 RibP	SLE IMPP
	Speckled	Jo-1	IMPP

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Hu: Anti-Neuronal Nuclear Antibodies

Anti-Hu antibodies: Stain neuronal nuclei; Nucleoli not stained

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3/21/2024