Anti-Nuclear (ANA; HEp-2 IFA) & Cytoplasmic Antibody: Staining Patterns
| ANA Pattern | Antigens | Diagnosis | Images: Link | |
| Nuclear |
Homogeneous |
dsDNA Nucleosomes Histones |
SLE, Drug-induced Hepatitis Juvenile arthritis |
 HEp-2 cell IIF Link |
| Speckled |
Scl70 Sm U1RNP U4/U6RNP U5RNP U11/12RNP RNA Pol III Ku antibody RuvBl 1/2 SUMO (SAE) |
SLE SSc MCTD Sjögren |
 HEp-2 cell IIF Link |
|
| Fine Speckled |
SS-A/Ro SS-B/La Mi-2 TIF1-γ & -β Ku antibody |
Systemic Sclerosis Dermatomyopathy |
Link | |
|
Nucleolar |
PM/Scl Th/To Fibrillarin |
SSc BCIM |
 HEp-2 cell IIF Link |
|
| Dots |
SMN p80-coilin |
None | ||
| Multiple Dots |
Sp-100 PML proteins SUMO (SAE) MJ/NXP-2 |
Dermatomyopathy | Link | |
| Centromere | Centromere CENP-B |
SSc: Limited Cutaneous/CREST |
 Link |
|
| Peripheral | RNP Sm |
Systemic Sclerosis |
 Link |
|
| Neuronal | Hu | Sensory Neuronopathy Limbic enephalitis Ataxia Autonomic |
 |
|
| Cytoplasmic | Fine Speckled |
RuvBL 1/2 eiF2b PL7 PL12 RibP |
SLE IMPP |
|
| Speckled |
Jo-1 | IMPP | ||
| Granular | HMGCR |
Muscle Fiber Necrosis/IMPP |
||
| None | SRP | Immune Myopathy |
||
Hu: Anti-Neuronal Nuclear Antibodies
|
|
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1/23/2025