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Rituximab Infusion Protocol

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Admission testing
  1. Patient is admitted for treatment by staff.
  2. On admission
  3. Patient is evaluated: Obtain
  4. Outcome assessments
  5. Laboratory
IV Access
  1. Start IV heparin lock
  2. Start normal saline at 100 cc/hr
  3. Run saline at keep vein open (kvo) rate during infusion
Rituximab Infusions Precautions
  1. Problems: Contact the Neuromuscular fellow immediately.
  2. Notify MD for
  3. Activity while in treatment center: Patient may be up ad lib
  4. After infusion is finished
  1. Patient should be sent home on their regular medicines
  2. Follow-up in the Neuromuscular clinic: Exam & Lab testing every 3 months; 2 months after final infusion.
  3. Questions or problems: Patient should call Neuromuscular office at 314-362-6981.
Follow-up testing: Blood is drawn every 2 to 3 months for

Levine, TD, Pestronk, A. IgM antibody-related polyneuropathies: Treatment with B-cell depletion chemotherapy using rituximab.
Neurology 1999;52:1701-1704.

Pestronk A, Florence J, Miller T, Choksi R, Al-Lozi MT, Levine TD. Treatment of IgM antibody-associated polyneuropathies using Rituximab.
J Neurol Neurosurg Psychiat 2003;74:485-489.
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