Neuromuscular

X-linked Myopathy with Excessive Autophagy


H & E stain


H & E stain   From J Mandell
Myopathic changes
  • Muscle fiber size: Varied
  • Endomysial connective tissue: Increased
  • Internal nuclei

H & E stain   From J Mandell
Vacuoles: Small & Clear

H & E stain
Myopathic changes

H & E stain

H & E stain

H & E stain

VvG stain

NADH stain


Esterase stain   From J Mandell

Vacuoles in Muscle fiber cytoplasm
  Many stain for Esterase


Esterase stain


Dystrophin stain
Vacuoles: Stain for Dystrophin & other membrane proteins


δ-Sarcoglycan stain
Vacuoles: Stain for membrane proteins, including δ-Sarcoglycan

δ-Sarcoglycan stain


Caveolin-3 stain
Vacuoles: Stain for membrane proteins, including Caveolin-3

Caveolin-3 stain


LAMP2 stain
LAMP2 stain
  XMEA (Above)
  Control (Below)

LAMP2 stain


ATPase pH 4.3 stain

ATPase pH 4.3 stain

Return to: X-linked myopathy with excessive autophagy
Also see: Autophagic vacuoles with sarcolemmal features
Return to: Pathology index
Return to: Neuromuscular Home Page

9/30/2021