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Chronic Neuropathy with IgG vs Neurofascin 140, 155 & 186

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Myelin Pathology

Gomori trichrome stain

Myelin stain: Reduced red in scattered myelin sheaths (Arrow; Above)
Irregular structure (Arrow; Below)

VvG stain

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Autophagic Myelin
  Myelin sheaths stain for acid phosphatase

Acid phosphatase stain

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Irregular Myelin Structure
  Irregular co-localization of P0 & MBP (Red areas within myelin sheaths)
  See: Control nerve

P0 (Green) + MBP (Red) stain

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Myelin Sheaths: Structure & Shape Irregular

Toluidine blue stain

Toluidine blue stain

Myelin Sheaths: Structure & Shape Irregular (Arrows)

Toluidine blue stain

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Neurofilament (Green) + Myelin Basic Protein (Red)

Many small axons within thick myelin sheaths

Neurofilament (Green) + P0 Protein (Red)

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Myelin Sheaths vs Axons

Myelin Sheath Morphology
  Thick for axon size
  Shapes: Irregular
Myelin Sheath Morphology
  Thick for axon size
  Shapes: Irregular

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Myelin Sheath Morphology
  Thick for axon size
  Shapes: Irregular, Folded

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Axons

Scattered axons: Other morphology
Dystrophic
  Dark axoplasm
  Thinly myelinated
Small, unmyelinated axons may be
  Reduced in number
  Singletons: Only one small axon within non-myelinating Schwann cell

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Dystrophic Axons
  Dark cytoplasm with tubuloreticular profiles
  Unmyelinated or thinly myelinated
  Present in a cluster

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Axon & Myelin sheath: Abnormal
  Axon: Abnormal axoplasm
  Myelin Sheath: Partial degradation

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Myelinated Axons: Thin sheath
Unmyelinated axons
  Reduced numbers per Schwann cell
Axon loss
  Schwann cells with no axons & collagen pockets

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Loss of Small axons: Moderate
  Scattered non-myelinating Schwann cells with no axon (Red)

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Denervated Schwann Cells: Scattered
  Scattered non-myelinating Schwann cells costain for NCAM & P0

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Return to: Neurofascin Antibodies
Return to: Neuromuscular Home Page

1/14/2025