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Neurofibroma

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Histology   Background     Disordered & Loose     Mucoid substance: Acid mucopolysaccharide     Collagen: Fibrils; Shredded carrot A; B     Vessels: Thin walled vs Schwannoma   Cell anatomy     Shape: Elongated & Wavy     Interlacing     Hyperchromatic     Nuclei: Spindle-shaped   Cell types within tumor: Mixed     Schwann cells     Perineurial cells     Fibroblasts     Lymphocytes     Mast cells     Macrophages     Axons: Myelinated & Unmyelinated   Immunoreactivity of tumor cells     S-100: Positive but Varied; Less than Schwannoma     SOX10     Basal lamina: Collagen IV     CD34 (Fibroblasts)     Not: Epithelial membrane antigen (EMA); CALB2

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H&E stain

Neurofibroma: Structure
  Disordered & Loose
  Mucoid substance: Acid mucopolysaccharide
  Collagen: Fibrils; Shredded carrot

H&E stain

H&E stain

H&E stain

H&E stain

Collagen: Fibrils; Shredded carrot appearance

H&E stain

H&E stain

H&E stain

Collagen: Fibrils; Shredded carrot appearance

H&E stain

H&E stain

H&E stain

H&E stain

Cell anatomy
  Shape: Elongated & Wavy
  Interlacing
  Hyperchromatic
  Nuclei: Spindle-shaped

H&E stain

H&E stain

H&E stain

Cell anatomy
  Shape: Elongated & Wavy
  Interlacing
  Hyperchromatic
  Nuclei: Spindle-shaped

H&E stain

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Neurofibroma: Neoplasm contains myelinated axons

H&E stain

Myelinated Axons (Arrows): Within neoplasm substance

H&E stain

H&E stain

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Neurofibroma: Varied staining for S100

S100 stain

S100: Moderately dark staining of neurofibroma tissue

S100 stain

S100 stain

S100 stain

S100: Moderately dark staining of cells in neurofibroma tissue
  Frequency of cell staining varies in different neoplasm regions

S100 stain

S100 stain

S100 stain

S100 stain

S100 stain

S100: Moderately dark staining in neurofibroma tissue
  Tissue staining varies in different neoplasm regions

S100 stain

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Collagen IV stain

Collagen IV staining
  Connective tissue in most regions of the neoplasm

Collagen IV stain

Collagen IV stain

Collagen IV staining
  Connective tissue in most regions of the neoplasm
    Varied densities of connective tissue
  Vessels have thin walls

Collagen IV stain

Collagen IV stain

Collagen IV stain

Collagen IV staining
  Connective tissue in most regions of the neoplasm
    Varied densities of connective tissue
  Vessels have thin walls

Collagen IV stain

Collagen IV stain

Collagen IV stain

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3/30/2025